Pathology or norm - a common protein will tell
By the term total protein is meanta vast concept that includes all the proteins that are contained in the blood, and there are really a huge number of them. All of them are different in structure, function and chemical-physical properties. Basically, the division occurs on albumins and globulins, but fibrinogen is also present.
Normally, the amount of total protein depends onhuman age. In a newborn who has not turned a month, this index is from 46.0 to 68.0 g / liter, in a premature baby this indicator can be lowered, the norm in this case ranges from 36 to 60 g / liter. Total protein in children - the norm of this indicator from one month to a year is 48.0-76.0, and from year to 16 years - 60.0-80.0 g / liter. In adults, a person produces a total protein in the range of 65.0 to 85.0 grams per liter, and after 60 years this indicator can be reduced by about 2 g / l.
This indicator helps to evaluate the indicatorshemostasis, thanks to which blood acquires its basic properties, such as viscosity and fluidity. The concentration of protein in the blood depends on the ability of the elemental elements to be kept in a suspended state. Also at the expense of proteins transport of various substances, protection of an organism is carried out.
In the clinic is not uncommon diseases in whichthe indicator of the total protein of serum is changing. The analysis of a blood will help to establish, a pathology in this case or opposite, norm or rate. A common protein will give the doctor a clearer idea. Increased its content is called hyperproteinemia, and decreased - hypoproteinemia.
Increased total protein
The increase in the total protein can be as absolute,both relative and relative. There are a number of diseases in which the total protein is relatively elevated. The norm in men and women in this indicator is the same, but with burns, peritonitis, intestinal obstruction, vomiting or vice versa, diabetes, diabetes, sugar, kidney disease, or increased sweating, this indicator rises relatively.
If there is an absolute increase, then thistestifies that in the body there is a process that can harm him, and this is not the norm for him. The total protein in the blood at the same time increases due to pathological fractions, which are called paraproteins, and also due to proteins of inflammation. In this case, it is worthwhile to suspect myelomium disease, the protein at it rises to 120-160 g / l, Hodgkin's disease and polyarthritis, chronic or acute infection, active hepatitis, cirrhosis, sarcoidosis and autoimmune diseases.
Decrease in the total protein
Hypoproteinemia can also be absolute orrelative, which is also not the norm. Total protein decreases with water load, absence or decrease in urine, cardiac decompensation, large intravenous infusion of glucose solution, when renal excretion is impaired, when an increased antidiuretic hormone that delays urinary excretion.
Absolute decline is due to loweringalbumin, which can also be characterized as not the norm. The total protein decreases if there is insufficient protein intake with food or increased excretion of it - with starvation, enteritis, colitis. Its production decreases with hepatitis, cirrhosis, intoxication, congenital pathology - albuminemia, Wilson-Konovalov's disease. Increased disintegration can occur with oncology, burns, increased thyroid function, in trauma, after surgical treatment, with fever or prolonged treatment with corticosteroids. The index of total protein in ascites or pleurisy decreases when it is lost with the fluid, or with kidney diseases. Physical activity, as well as the last months of pregnancy and lactation, contribute to hypoproteinemia in women.